(MedPage Today) -- The FDA granted full approval to the menin inhibitor revumenib (Revuforj) for adults and children 1 year and older with relapsed/refractory acute leukemia and a lysine methyltransferase 2A gene (KMT2A) translocation.
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FDA Approves First Menin Inhibitor for Acute Leukemia
via medpagetoday.com
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Ablation Bests Drugs for Ventricular Tachycardia After Heart Attack
via medpagetoday.com
(MedPage Today) -- CHICAGO--For patients with ventricular tachycardia (VT) and ischemic cardiomyopathy, going right to catheter ablation improved outcomes compared with trying antiarrhythmic drugs first, the VANISH2 trial showed.
Death or...
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JAK Inhibitor Succeeds in Giant Cell Arteritis Trial
via medpagetoday.com
(MedPage Today) -- WASHINGTON--Giant cell arteritis (GCA) can be successfully treated with the oral Janus kinase (JAK) inhibitor upadacitinib (Rinvoq), allowing corticosteroids to be withdrawn, results of a phase III trial indicated.
Among...
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What New Warning Is on GLP-1 Drug Labels?
via medpagetoday.com
(MedPage Today) -- You passed medical training, now see if you can pass our weekly quiz
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Tirzepatide Officially Puts GLP-1 Meds on the Map for Obesity-Related Heart Failure
via medpagetoday.com
(MedPage Today) -- CHICAGO--A long-acting GIP/GLP-1 receptor agonist conferred significant clinical benefit for people with obesity and accompanying heart failure with preserved ejection fraction (HFpEF), according to the SUMMIT trial.
Incident...
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Intensive Blood Pressure Control Benefits People With Type 2 Diabetes Too
via medpagetoday.com
(MedPage Today) -- CHICAGO--The cardiovascular outcome benefit of a tighter systolic blood pressure target was affirmed in patients with type 2 diabetes in the randomized BPROAD trial from China.
A target of less than 120 mm Hg reduced a composite...
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Multiple Chronic Conditions and Death; Diabetes Treatment for Gout
via medpagetoday.com
(MedPage Today) -- TTHealthWatch is a weekly podcast from Texas Tech. In it, Elizabeth Tracey, director of electronic media for Johns Hopkins Medicine in Baltimore, and Rick Lange, MD, president of the Texas Tech University Health Sciences Center...
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Could Avian Flu Cause Our Next Pandemic?
via medpagetoday.com
(MedPage Today) -- Colleagues, it's time to wake up and smell the coffee. Or, for a true reality check, just scan the Department of Agriculture's frequently-updated map and tables naming the many animals that have tested positive for highly pathogenic...
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Clozapine's REMS Program on the Chopping Block at Upcoming FDA Meeting
via medpagetoday.com
(MedPage Today) -- Is a risk evaluation and mitigation strategy (REMS) still needed for clozapine? That's what a joint meeting of two FDA advisory committees will discuss on Tuesday.
Risk management requirements for the atypical antipsychotic...
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Physician Groups Quiet on RFK Jr. Nomination for HHS Secretary
via medpagetoday.com
(MedPage Today) -- The response from physician groups to President-elect Donald Trump's nomination of Robert F. Kennedy Jr. for HHS secretary has been rather measured so far.
Take for example the American Academy of Pediatrics (AAP). "[This] nomination...
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Higher BP Linked to Faster Visual Field Progression in Glaucoma
via medpagetoday.com
(MedPage Today) -- Higher mean blood pressure (BP) levels were associated with faster rates of visual field progression in patients with glaucoma, according to a retrospective cohort study.
Among 985 patients, the interaction terms of higher mean...
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A Potential Reason Behind COVID Vaccines' Waning Benefit
via medpagetoday.com
(MedPage Today) -- The inability of COVID vaccines to reach the long-lived plasma cell compartment in the bone marrow may explain their waning protection compared with vaccines for influenza or tetanus, according to a recent study published in...
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Response Duration After Stopping Enfortumab Vedotin in Bladder Cancer
via medpagetoday.com
(MedPage Today) -- Patients with metastatic urothelial carcinoma who achieved a complete response after more than 8.5 months of single-agent enfortumab vedotin (Padcev) were able to be off treatment for over 2 years before needing to restart therapy...
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MEK Inhibitor Scores Big Win in Adults, Children With Neurofibromatosis Type 1
via medpagetoday.com
(MedPage Today) -- Almost half of adults and children with neurofibromatosis type 1 (NF1) responded to the investigational MEK inhibitor mirdametinib, a large multicenter study of the rare condition showed.
Overall, 53 of 114 patients met response...
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How Often Do Doctors Use New Weight-Loss Drugs in Kids?
via medpagetoday.com
(MedPage Today) -- This story is part of a series called "Ozempic: Weighing the Risks and Benefits." It was produced in part through a grant from the NIHCM Foundation.
When Fatima Cody Stanford, MD, MPH, MPA, attended a holiday party thrown by...
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NMO Drug Looks Good for IgG4-Related Disease
via medpagetoday.com
(MedPage Today) -- WASHINGTON--Patients with IgG4-related disease appeared to benefit from inebilizumab (Uplizna), currently approved for neuromyelitis optica (NMO), in a pivotal clinical trial.
Just 10% of patients treated with the drug in...
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An Update on Therapeutics for COVID-19
via medpagetoday.com
(MedPage Today) -- Although the general population now has at least some immunity against COVID-19, the consequences of severe disease are frequently overlooked for certain patient populations, such as those with comorbidities or immune compromise...
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Group Sues Tennessee Over Racial Requirements for Medical Boards
via medpagetoday.com
(MedPage Today) -- A nonprofit dedicated to opposing diversity initiatives in medicine has filed a federal lawsuit challenging the requirements surrounding the racial makeup of key medical boards in Tennessee.
The Virginia-based Do No Harm filed...
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Nurse Suicides High During the Pandemic, but Feared Surge Never Materialized
via medpagetoday.com
(MedPage Today) -- Female nurses' suicide risk remained higher but didn't worsen through the COVID-19 pandemic compared with other women, according to a large retrospective cohort study.
Female nurses had 21% and 41% higher suicide rates than...
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Big Comeback for Myeloma Drug; DIY Cancer Therapy; Gut Clues to Bladder Cancer
via medpagetoday.com
(MedPage Today) -- GSK announced that belantamab mafodotin (Blenrep) plus bortezomib (Velcade) and dexamethasone improved overall survival in relapsed/refractory multiple myeloma as compared with daratumumab (Darzalex) plus bortezomib and dexamethasone...
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MedPod Today: What Happens to Healthcare Under Trump?
via medpagetoday.com
(MedPage Today) -- The following is a transcript of the podcast episode:
Rachael Robertson: Hey, everybody. Welcome to MedPod Today, the podcast series where MedPage Today reporters share deeper insight into the week's biggest healthcare stories...
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Confidentiality Clauses Are Killing Patients
via medpagetoday.com
(MedPage Today) -- Our most egregious mistakes in medicine often become lawsuits. A common denominator of those lawsuits is that they should prevent these situations from happening to another patient. However, the worst of these cases are settled...
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Are Doctors Costing Hospitals $300K Per Year?
via medpagetoday.com
(MedPage Today) -- With hospitals now "subsidizing" their physician workforce to the tune of more than $300,000 per doctor each year, current models of physician employment aren't sustainable, a new report suggested.
In the third quarter of 2024...
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Primary Biliary Cholangitis Incidence and Prevalence Growing
via medpagetoday.com
(MedPage Today) -- Primary biliary cholangitis (PBC) has typically been considered a rare condition, with a pooled global estimated incidence of two per 100,000 people per year and an estimated prevalence of 15 per 100,000 people per year. But...
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Managing Primary Biliary Cholangitis Progression and Symptoms
via medpagetoday.com
(MedPage Today) -- Once clinical suspicion has been established for primary biliary cholangitis (PBC), the "serologic hallmark" of the autoimmune disease are anti-mitochondrial antibodies (AMA), present in approximately 90% to 95% of all patients...
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Why I Fight for Reproductive Rights in a Restrictive State
via medpagetoday.com
(MedPage Today) --
Welcome to MedPage Today's "White Coat Chronicles," a short-form feature series where we follow Emilie "Mia" Mathura, DO, MSPH, during her first year of residency in ob/gyn.
In this week's edition, Mathura shares her firsthand...
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RFK Jr. Spurs FDA Resignations; Chatbot to User: 'Please Die'; Dating Apps and STIs
via medpagetoday.com
(MedPage Today) -- Note that some links may require registration or subscription.
FDA staff members are considering leaving after president-elect Donald Trump nominated Robert F. Kennedy Jr. for HHS Secretary. (NBC News)
Meanwhile, the stocks...
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Larger Study Supports Safety of Tetracyclines During Early Pregnancy
via medpagetoday.com
(MedPage Today) -- The link between first trimester tetracycline exposure and major congenital malformations (MCMs) was not supported by a large cohort study based on Sweden's national registers.
Incidence of any MCM diagnosed in the first year...
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First Brain-Delivered Gene Therapy Approved for AADC Deficiency
via medpagetoday.com
(MedPage Today) -- The FDA granted accelerated approval to eladocagene exuparvovec (Kebilidi) to treat children and adults with aromatic L-amino acid decarboxylase (AADC) deficiency, the agency announced Thursday.
The treatment is the first approved...
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Adding HIPEC Boosts Survival in Recurrent Ovarian Cancer
via medpagetoday.com
(MedPage Today) -- Adding hyperthermic intraperitoneal chemotherapy (HIPEC) to cytoreductive surgery significantly improved overall survival (OS) in women with platinum-sensitive, recurrent epithelial ovarian carcinoma, a phase III randomized trial...
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