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• Early Parkinson's Drug Hits Targets in Phase III Studies

  09-04-2025 18:31 via medpagetoday.com
  (MedPage Today) -- SAN DIEGO--Both fixed and flexible doses of investigational tavapadon met their primary endpoint in phase III trials of early Parkinson's disease.
  In the TEMPO-1 (fixed dose) and TEMPO-2 (flexible dose) studies, participants...
  
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• More Inclusive LGBTQ+ Language Can Bring Tangible Benefits

  08-05-2025 17:00 via medpagetoday.com
  (MedPage Today) -- Using language that's more inclusive of lesbian, gay, bisexual, transgender, queer/questioning, and more (LGBTQ+) patient populations may help improve the patient-clinician relationship and make data from patient care and clinical...
  
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• Minor Papilla Sphincterotomy Did Not Reduce Risk of Acute Pancreatitis

  08-05-2025 16:50 via medpagetoday.com
  (MedPage Today) -- Minor papilla endoscopic sphincterotomy did not reduce the risk of acute pancreatitis in patients with acute recurrent pancreatitis and pancreas divisum, a sham-controlled randomized trial showed.
  Among 148 patients, 34.7% of...
  
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• Need Help With Lupus Nephritis Management? ACR Has Your Back.

  08-05-2025 16:10 via medpagetoday.com
  (MedPage Today) -- Over the past dozen years, treatment approaches in lupus nephritis (LN) have changed substantially, and this is reflected in a long-awaited update to the American College of Rheumatology's (ACR) official guideline on the topic...
  
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• Who Is Trump's Surgeon General Pick? Drug Cost Executive Order; Combo Flu-COVID Vax

  08-05-2025 15:28 via medpagetoday.com
  (MedPage Today) -- Note that some links may require registration or subscription.
  Who is Casey Means, MD? A profile of the new nominee for U.S. Surgeon General. (AP)
  President Trump is expected to sign an executive order pushing down drug costs...
  
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• 'Armored' CAR T Cells Highly Active in Lymphoma After Prior CAR-T Failure

  07-05-2025 23:43 via medpagetoday.com
  (MedPage Today) -- A next-generation, anti-CD19 enhanced (or "armored") CAR T-cell product showed promising efficacy and safety in a phase I trial of lymphoma patients who had previously failed anti-CD19 CAR T-cell therapy.
  Among 21 patients...
  
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• White House Yanks Pick for Surgeon General

  07-05-2025 23:25 via medpagetoday.com
  (MedPage Today) -- The White House is withdrawing the nomination of a former Fox News medical contributor Janette Nesheiwat, MD, for U.S. surgeon general, marking at least the second health-related pick from President Donald Trump to be pulled...
  
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• RFK Jr. Unveils Autism Patient Database Project

  07-05-2025 23:14 via medpagetoday.com
  (MedPage Today) -- The NIH and the Centers for Medicare & Medicaid Services (CMS) will build a data platform to conduct research across claims data, electronic health record (EHR) data, and consumer wearables, HHS announced Wednesday.
  The...
  
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• BCG Revaccination Hopes Dim for Tuberculosis Prevention

  07-05-2025 23:00 via medpagetoday.com
  (MedPage Today) -- Bacille Calmette-Guérin (BCG) revaccination didn't help prevent sustained Mycobacterium tuberculosis infection in initially uninfected adolescents without HIV in a phase IIb trial.
  Getting the BCG shot in the trial did...
  
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• House GOP Backs Off Some Medicaid Cuts as Report Says Millions Would Lose Healthcare

  07-05-2025 22:42 via medpagetoday.com
  (MedPage Today) -- House Republicans appear to be backing off some, but not all, of the steep reductions to the Medicaid program as part of their big tax breaks bill, as they run into resistance from more centrist GOP lawmakers opposed to ending...
  
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• Afatinib Improved PFS in Lung Cancer With Uncommon Mutations

  07-05-2025 22:24 via medpagetoday.com
  (MedPage Today) -- Patients with advanced non-small cell lung cancer and uncommon EGFR mutations lived almost twice as long without disease progression with the targeted agent afatinib (Gilotrif) versus chemotherapy, a randomized trial from Japan...
  
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• Oral Obicetrapib Takes Lipid Lowering to Another Level in Trials

  07-05-2025 21:59 via medpagetoday.com
  (MedPage Today) -- Obicetrapib provided dramatic reductions in LDL cholesterol, without noticeable side effects, in a phase III trial of high-risk individuals already on maximal lipid-lowering therapy.
  In adults with heterozygous familial hypercholesterolemia...
  
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• Test Scores Never Defined My Competence as an Effective Clinician

  07-05-2025 20:44 via medpagetoday.com
  (MedPage Today) -- In late April, the White House issued an executive order instructing accrediting bodies to rely only on "data on program-level student outcomes ... without reference to race, ethnicity, or sex." Many interpreted the order as...
  
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• Meds Without Therapy Declining; Conversion Therapy Effects; Trial Diversity Needed

  07-05-2025 19:55 via medpagetoday.com
  (MedPage Today) -- Psychotherapy became more popular in outpatient mental health care in recent years, while psychotropic medication without psychotherapy became less common. (American Journal of Psychiatry)
  Universal routine depression screening...
  
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• Study Findings Do Not Support Omitting Surgery for Breast Cancer

  07-05-2025 18:32 via medpagetoday.com
  (MedPage Today) -- Adding tumor-bed biopsy to trimodality imaging after neoadjuvant chemotherapy in patients who had clinical complete response did not reliably predict pathological complete response (pCR) among breast cancer patients, findings...
  
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• North Dakota Is the 11th State With a Measles Outbreak. Here's What to Know.

  07-05-2025 18:13 via medpagetoday.com
  (MedPage Today) -- North Dakota is the 11th state in the U.S. with a measles outbreak, logging its first cases since 2011.
  The CDC's confirmed measles case count is 935, more than triple the amount seen in all of 2024. The 3-month outbreak in...
  
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• Kennedy's 'Secret' Vax Database; Havoc at VA Hospitals; NIH Clinical Center Unsafe?

  07-05-2025 17:20 via medpagetoday.com
  (MedPage Today) -- Welcome to the latest edition of Investigative Roundup, highlighting some of the best investigative reporting on healthcare each week.
  Kennedy's 'Secret' Vax Database
  Now that HHS Secretary Robert F. Kennedy Jr. oversees the...
  
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• AI Tool Helped Endocrinologists Titrate Insulin for Hospitalized Diabetes Patients

  07-05-2025 17:00 via medpagetoday.com
  (MedPage Today) -- An artificial intelligence (AI) tool was just as good as senior endocrinologists at titrating insulin in the hospital, a Chinese randomized trial found.
  Among 149 hospitalized patients with type 2 diabetes, those who had regimens...
  
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• Senator's Mental Health; Hepatitis A Outbreak; WHI Funding Officially Restored

  07-05-2025 15:29 via medpagetoday.com
  (MedPage Today) -- Note that some links may require registration or subscription.Sen. John Fetterman (D-Pa.) dismissed a recent report detailing concerns about his mental health, calling it a "hit piece." (The Hill)
  The NIH laid off several...
  
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• Taking Time for a Second Opinion About Breast Cancer Treatment

  06-05-2025 23:43 via medpagetoday.com
  (MedPage Today) -- Taking time to get a second opinion on breast cancer treatment did not significantly alter the time to treatment, which still occurred within the currently recommended timeframe, a retrospective cohort study showed.
  Overall...
  
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• Trial Helps Unravel Migraine-Depression Knot

  06-05-2025 22:49 via medpagetoday.com
  (MedPage Today) -- Fremanezumab (Ajovy) reduced depression symptoms and monthly migraine attacks in people with episodic or chronic migraine and major depressive disorder, the phase IV UNITE trial showed.
  The mean change from baseline in monthly...
  
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• H5N1 Bird Flu Cases Have Slowed in Animals and People

  06-05-2025 22:45 via medpagetoday.com
  (MedPage Today) -- Detections of H5N1 avian influenza have slowed in both animals and humans, but continued surveillance is warranted, CDC researchers said.
  In dairy cattle, cases surged over the fall and early winter but eased in January, while...
  
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• Vinay Prasad, Critic of COVID Measures, Picked as FDA's Top Vaccine Official

  06-05-2025 22:26 via medpagetoday.com
  (MedPage Today) -- Vinay Prasad, MD, MPH, a frequent critic of the FDA and COVID-19 lockdowns and vaccination policies, will be the next director of FDA's Center for Biologics Evaluation and Research (CBER), the center that oversees vaccine approvals...
  
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• AI Topped Docs in Quality, Empathy of Responses to Patient Questions on GI Cancers

  06-05-2025 20:43 via medpagetoday.com
  (MedPage Today) -- SAN DIEGO--Research presented at Digestive Disease Week (DDW) included studies on the quality and empathy of artificial intelligence (AI) responses versus physician responses to patient questions about gastrointestinal cancers...
  
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• Depression 15 Years Before Dementia; Hand Movements and Autism; TBI Research Cut

  06-05-2025 20:19 via medpagetoday.com
  (MedPage Today) -- Depressive symptoms rose progressively in the 15 years leading up to dementia diagnosis, with the highest elevations occurring in non-Alzheimer's dementia, according to a case-control study in France. (Journal of Neurology, Neurosurgery...
  
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• Banning PFAS Would Jeopardize Millions of Medical Devices

  06-05-2025 20:13 via medpagetoday.com
  (MedPage Today) -- A key component of life-saving medical devices has been placed in the crosshairs by government regulators, jeopardizing care for millions of Americans.
  State and federal policymakers are targeting a class of 15,000 chemicals...
  
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• Wegovy Pill Under Review; FDA Lifts Obesity Trial Clinical Hold; SGLT2s and Surgery

  06-05-2025 19:52 via medpagetoday.com
  (MedPage Today) -- The FDA will decide whether to approve a once-daily, 25 mg oral formulation of semaglutide (Wegovy) by the end of 2025. If approved, it would be the first GLP-1 pill indicated for obesity, said maker Novo Nordisk.
  The rate of...
  
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• Zoster Vax & Heart Disease; Jewel WCD OK'd; Carotid Revascularization for Low-Risk?

  06-05-2025 19:28 via medpagetoday.com
  (MedPage Today) -- In a nationwide Korean study, live zoster vaccination was linked with lower risks of heart disease, including major adverse cardiovascular events, heart failure, ischemic heart disease, and other outcomes. (European Heart Journal...
  
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• Most Babies Protected Against RSV During First Season Immunization Was Available

  06-05-2025 18:43 via medpagetoday.com
  (MedPage Today) -- During the first respiratory syncytial virus (RSV) season in which a maternal vaccine and a monoclonal antibody for infants were available, most infants were immunized via either intervention, according to an analysis of Vaccine...
  
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• Blood Test May Predict MASLD Up to 16 Years Earlier

  06-05-2025 18:24 via medpagetoday.com
  (MedPage Today) -- SAN DIEGO--A new blood test can predict the development of metabolic dysfunction-associated steatotic liver disease (MASLD) up to 16 years before it occurs, according to a retrospective cohort study analyzing proteomics data...
  
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